Reactivity: Human
Articlecode: 11-NTN-H
Product: Neurturin (NTN), human, recombinant
Catalog #: 11-NTN-H
Amount: 5 ìg
DESCRIPTION: Human Neurturin (NTN) and Human GDNF comprise a family of TGF-beta related neurotrophic factor which have trophic influences on a variety of neuronal populations. Neurturin promotes the survivability of certain sympathetic and sensory neurons through interaction with distinct set of GDNF-like receptors. Neurturin is a homodimeric 23.6 kDa protein consisting of two identical subunits each containing 103 amino acid residues
SOURCE: Escherichia coli
PURITY: Greater than 98.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Anion-exchange FPLC
DIMERS & AGGREGATES: <1% as determined by silver stained SDS-PAGE gel analysis
ENDOTOXIN: Less than 0.1 ng/µg (IEU/µg) of rHuNTN
PROTEIN CONTENT: Protein quantitation was carried out by two independent methods:
1) UV spectroscopy at 280 nm.
2) Analysis by RP-HPLC, using a standard solution of NTN as a Reference Standard.
FORM: Purified
STORAGE: -20°C, avoid freezing and thawing cycles after reconstitution
BIOLOGICAL ACTIVITY: rHuNTN is fully biologically active when compared to standard.
Human Neurturin at a concentration of 100 ng/ml will support the survival of 65% of newborn rat sympathetic neurons
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