Format: purified - Reactivity: human, rat, mouse - Synonym: PKC theta
Articlecode: PM2171
Clone: M217
Isotype: Mouse IgG2a
Applications: WB, ELISA
WB: 1:1000 ELISA: 1:2000 IP: IC:
Synonym: PKC theta
BACKGROUND:
The Protein Kinase C (PKC) family of homologous serine/threonine protein kinases is involved in a number of processes such as growth, differentiation, and cytokine secretion. At least eleven isozymes have been described. PKC consists of a single polypeptide chain containing four conserved regions (C) and five variable regions (V). The N-terminal half interacts with PKC activators Ca2+, phospholipid, diacylglycerol, or phorbol ester, while the C-terminal half contains the catalytic domain. The conventional PKC subfamily (alpha, beta I, beta II, and gamma) is regulated by both Ca2+ and diacylglycerol. The PKC pathway represents a major signal transduction system that is activated following ligand-stimulation of transmembrane receptors by hormones, neurotransmitters and growth factors. The phosphorylation of multiple sites in PKCs regulates their activity.
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