Reactivity: human, mouse
Articlecode: 14-9057-81
Contents: Rabbit anti-human, mouse SARM (SAM and ARM-containing protein) (C-terminus) polyclonal
Catalog Number: 14-9057
Sizes: 10 ug, 50 ug
Formulation: Phosphate buffered saline, pH 7.2, less than or equal to 0.09% NaN3
Storage Conditions: Store at 4°C.
Avoid repeated freeze/thaw cycles.
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Available Formats of This Product
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14-9057
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N/A
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N/A
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Description
This polyclonal antibody reacts with SARM (SAM and ARM-containing protein), which is a TIR (Toll/IL-1 receptor) domain containing adaptor protein thought to play a role in Toll-Like Receptor (TLR) signal transduction. In addition to the TIR domain, SARM also contains sterile alpha (SAM) and HEAT/Armadillo (ARM) motifs. SAM domains can homo- and hetero-oligomerise and are involved in protein-protein interactions. The ARM motif is a 40-amino acid tandem repeat that mediates the interaction between â-catenin and its ligands, and can form interactions with other proteins, for example, the small GTPase Ras.
Applications Reported
For research use only, not for diagnostic or therapeutic use. This rabbit anti-human, mouse SARM polyclonal antibody has been reported for use in immunoblotting (WB), and immunohistochemical staining.
Applications Tested
This rabbit anti-human, mouse SARM polyclonal antibody has been tested by western blot analysis of Daudi cell lysates at a concentration of 2 ìg/ml.
References
Mink M, Fogelgren B, Olszewski K, Maroy P, Csiszar K. A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/beta-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans. Genomics. 2001 Jun 1;74(2):234-44.
Couillault C, Pujol N, Reboul J, Sabatier L, Guichou JF, Kohara Y, Ewbank JJ. TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM. Nat Immunol. 2004 May;5(5):488-94. Epub 2004 Mar 28.
Carty M, Goodbody R, Schroder M, Stack J, Moynagh PN, Bowie AG. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nat Immunol. 2006 Sep 10.
McGettrick AF, O'Neill LA. The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Mol Immunol. 2004 Jul;41(6-7):577-82. Review.
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