Reactivity: human, rat
Articlecode: 03-16070
Product: Anti-Substance P 4-11
Catalog #: 03-16070
Amount: 50 ml
CATEGORY: Rabbit Polyclonal
FORM: Serum containing 0.1% sodium azide
IMMUNOGEN: Synthetic Substance P 4-11 conjugated to thyroglobulin using CDI
DESCRIPTION/SPECIFICITY: Substance P occurs in nerve fibers of the central and peripheral nervous system and in endocrine cells of the gut. It stimulates smooth muscle contraction, gives rise to vasodilation and is involved in sensory functions. Substance P-containing tumors arising in the iliem are often associated with the carcinoid syndrome, characterized by flushing of the skin, diarrhea, broncho-constriction and sudden drops in blood pressure. Substance P is commonly found in the midgut carcinoids and some of the symptoms may be related to this peptide. Absorption with 10-100 mg SP 1-4 per ml diluted antiserum abolishes the staining.
ANTIGEN RECOGNIZED IN SPECIES (tested so far): Human, Rat
RECOMMENDED FOR POSITIVE CONTROL: Frozen sections of rat colon
APPLICATION: Immunohistochemistry, suitable for frozen and paraffin sections
WORKING DILUTION: 1:40 to 1:80 using PAP, with overnight incubation at 2-8°C
DILUTION BUFFER: 0.1 M PBS with 1% BSA and 0.1% Na-Azide
STORAGE: 2-8°C for immediate use, or at -20°C (aliquot)
REFERENCES:
Hardebo, JE et al. (1989) Neuroscience letters 101: 39-45
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