SDHB polyclonal, anti-human

SDHB polyclonal, anti-human

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In stock
SKU
A1029
Catalog Number: A1029

Isotype: Rabbit IgG

Applications: WB

Synonyms: CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIP
Background:
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Rearch Area:
Cancer, Signal Transduction, Cell Biology & Developmental Biology, Endocrine & Metabolism, Mitochondrial metabolism, Mitochondrial markers, Oxidative phosphorylation, Neuroscience, Neurodegenerative Diseases,

Cellular Location:
Matrix side, Mitochondrion inner membrane, Peripheral membrane protein,

Immunogen:
A synthetic peptide of human SDHB

Gene ID: 6390

Swiss prot: P21912

Calculated MW: 31kDa

Observed MW: 32kDa

Recommended dilution:
WB:1:500 - 1:2000

Positive samples:
liver, HL-60, 293

Purity:
Affinity purification

Storage Buffer:
Store at 4℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, pH7.3.

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