ACC1 (Phospho-Thr1196) polyclonal, anti-human, mouse, rat

ACC1 (Phospho-Thr1196) polyclonal, anti-human, mouse, rat

€0.00
In stock
SKU
AF7364
Catalog Number: AF7364

Isotype: Rabbit IgG

Applications: WB, ELISA

Synonyms: ACAC, ACACA, ACACA_HUMAN, ACACB, ACC alpha, ACC, ACC beta, ACC-alpha, ACC1, ACC2, ACCA, ACCB, Acetyl CoA carboxylase 1, Acetyl CoA carboxylase 2, Acetyl CoA carboxylase alpha, Acetyl CoA carboxylase beta, Acetyl Coenzyme A carboxylase alpha, Acetyl Coenzyme A carboxylase beta, Biotin carboxylase, COA1, COA2, HACC275, OTTHUMP00000164069, OTTHUMP00000164070, OTTHUMP00000164076, OTTHUMP00000240532,


Function:
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

Subcellular Location:
Cytoskeleton, Cytosol, Extracellular region or secreted, Mitochondrion, Nucleus

Post-translational Modifications:
Phosphorylation on Ser-1263 is required for interaction with BRCA1.

Subunit Structure:
Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity.

Specificity: Phospho-ACC1 (Thr1196) Antibody detects endogenous levels of ACC1 only when phosphorylated at Thr1196

Immunogen:
A synthesized peptide derived from human ACC1 around the phosphorylation site of Thr1196

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Concentration: 1mg/ml

predicted Mw: 265.554

Gene: ACACA
Uniprot ID: Q13085
Gene ID: 31

Buffer & Storage: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?C.Stable for 12 months from date of receipt

For research use only, not for use in diagnostic procedure.

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