CD167 (DDR1) (Phospho-Tyr520) polyclonal, anti-human, mouse, rat

CD167 (DDR1) (Phospho-Tyr520) polyclonal, anti-human, mouse, rat

€0.00
In stock
SKU
AF7361
Catalog Number: AF7361

Isotype: Rabbit IgG

Applications: WB, ELISA

Synonyms: CAK, CD 167, CD167, CD167 antigen-like family member A, CD167a, Cell adhesion kinase, DDR 1, DDR, DDR1, DDR1_HUMAN, Discoidin domain receptor, Discoidin domain receptor tyrosine kinase 1, Discoidin receptor tyrosine kinase, Discoidin receptor tyrosine kinase isoform a, EDDR 1, EDDR1, Epithelial discoidin domain receptor 1, Epithelial discoidin domain-containing receptor 1, Epithelial specific receptor kinase, HGK2, Mammarian carcinoma kinase 10, Mammary carcinoma kinase 10, MCK-10, MCK10, NEP, Neuroepithelial tyrosine kinase, Neurotrophic tyrosine kinase receptor type 4, NTRK 4, NTRK4, OTTHUMP00000029343, OTTHUMP00000029344, OTTHUMP00000029345, OTTHUMP00000029346, OTTHUMP00000029347, OTTHUMP00000164863, OTTHUMP00000164867, OTTHUMP00000222080, Protein-tyrosine kinase 3A, Protein-tyrosine kinase RTK-6, PTK 3, PTK 3A protein tyrosine kinase 3A, PTK3, PTK3A, Receptor tyrosine kinase NEP, RTK 6, RTK6, TRK E, TRKE, Tyrosine kinase DDR, Tyrosine kinase receptor E, Tyrosine-protein kinase CAK,


Function:
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

Subcellular Location:
Extracellular region or secreted, Plasma Membrane

Post-translational Modifications:
Autophosphorylated in response to fibrillar collagen binding.Glycosylation of Asn-211, but apparently not of Asn-260, Asn-371, or Asn-394, prevents autophosphorylation from occurring in the absence of collagen.

Subunit Structure:
Homodimer. Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen. Interacts (tyrosine phosphorylated) with SHC1. Interacts with SRC. Interacts with MYH9. Interacts with CDH1. Interacts with PTPN11. Interacts with NCK2.

Similarity:
The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates.Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Specificity: Phospho-DDR1 (Tyr520) Antibody detects endogenous levels of DDR1 only when phosphorylated at Tyr520

Immunogen:
A synthesized peptide derived from human DDR1 around the phosphorylation site of Tyr520

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Concentration: 1mg/ml

predicted Mw: 101.128

Gene: DDR1
Uniprot ID: Q08345
Gene ID: 780

Buffer & Storage: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?C.Stable for 12 months from date of receipt

For research use only, not for use in diagnostic procedure.

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