CD318 (CDCP1) polyclonal, anti-human

CD318 (CDCP1) polyclonal, anti-human

In stock
Catalog Number: AF7937

Isotype: Rabbit IgG

Applications: WB, ELISA

Synonyms: 9030022E12Rik, AA409659, CD 318, CD_antigen=CD318, CD318, CD318 antigen, CDCP 1, Cdcp1, CDCP1_HUMAN, CUB domain containing protein 1, CUB domain-containing protein 1, E030027H19Rik, FLJ13772, FLJ22375, FLJ22969, Membrane glycoprotein gp140, MGC31813, OTTHUMP00000164120, OTTHUMP00000209568, RGD1305578, SIMA 135, SIMA135, Subtractive immunization M plus HEp3 associated 135 kDa protein, Subtractive immunization M plus HEp3-associated 135 kDa protein, Transmembrane and associated with src kinases, TRASK,

May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.

Subcellular Location:
Extracellular region or secreted, Plasma Membrane

Post-translational Modifications:
Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5.N-glycosylated.A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease.

Subunit Structure:
Interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. Also interacts with SRC and PRKCG/protein kinase C gamma.

Specificity: CDCP1 Antibody detects endogenous levels of CDCP1

A synthesized peptide derived from human CDCP1

Purification: Immunogen affinity purified

Concentration: 1mg/ml

predicted Mw: 92.932

Gene: CDCP1
Uniprot ID: Q9H5V8
Gene ID: 64866

Buffer & Storage: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?C.Stable for 12 months from date of receipt

For research use only, not for use in diagnostic procedure.