DNAJC2/MPP11 polyclonal, anti-human, mouse

DNAJC2/MPP11 polyclonal, anti-human, mouse

In stock
Catalog Number: AF7934

Isotype: Rabbit IgG

Applications: WB, ELISA

Synonyms: AU020218, DnaJ (Hsp40) homolog subfamily C member 2, DnaJ homolog subfamily C member 2, Dnajc2, DNJC2_HUMAN, M phase phosphoprotein 11, M-phase phosphoprotein 11, MGC105894, MIDA1, MPHOSPH11, MPP11, OTTMUSP00000031226, ZRF1, Zrf2, ZUO1, Zuotin related factor 1, Zuotin related factor 2, Zuotin-related factor 1,

Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.

Subcellular Location:
Cytosol, Nucleus,

Post-translational Modifications:
Phosphorylated in M (mitotic) phase.

Subunit Structure:
Interacts (via ZRF1-UBD region) with ID1 (By similarity). Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.

The ZRF1-UBD region specifically recognizes and binds H2AK119ub. The ZRF1-UBD region is also involved in protein-protein interactions with other proteins, suggesting that it may be masked by some regulator, thereby preventing its association with H2AK119ub.

Specificity: DNAJC2/MPP11 Antibody detects endogenous levels of DNAJC2/MPP11

A synthesized peptide derived from human DNAJC2/MPP11

Purification: Immunogen affinity purified

Concentration: 1mg/ml

predicted Mw: 71.996

Gene: DNAJC2
Uniprot ID: Q99543
Gene ID: 27000

Buffer & Storage: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?C.Stable for 12 months from date of receipt

For research use only, not for use in diagnostic procedure.