Myt1 polyclonal, anti-human

Myt1 polyclonal, anti-human

In stock
Catalog Number: AF7935

Isotype: Rabbit IgG

Applications: WB, ELISA

Synonyms: cdc2 inhibitory kinase, DKFZp547K1610, FLJ20093, Membrane associated tyrosine and threonine specific cdc2 inhibitory kinase, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, MYT1, Myt1 kinase, PKMYT 1, Pkmyt1, PMYT1_HUMAN, PPP1R126, Protein kinase membrane associated tyrosine/threonine 1, Protein kinase Myt1, Protein phosphatase 1 regulatory subunit 126,

Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.

Subcellular Location:
Cytosol, Endoplasmic reticulum, Golgi apparatus, Nucleus,

Post-translational Modifications:
Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity.

Subunit Structure:
Interacts with CDC2-CCNB1 complex. Can also interact with PIN1 when phosphorylated by CDC2-CCNB1.

The membrane-association motif is essential for the localization to membrane of Golgi stack. According to some authors, it is a transmembrane domain; the existence of a transmembrane region is however unproven.Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.

Specificity: Myt1 Antibody detects endogenous levels of Myt1

A synthesized peptide derived from human Myt1

Purification: Immunogen affinity purified

Concentration: 1mg/ml

predicted Mw: 54.521

Gene: PKMYT1
Uniprot ID: Q99640
Gene ID: 9088

Buffer & Storage: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?C.Stable for 12 months from date of receipt

For research use only, not for use in diagnostic procedure.