Sin1 polyclonal, anti-human, mouse

Sin1 polyclonal, anti-human, mouse

In stock
Catalog Number: AF7936

Isotype: Rabbit IgG

Applications: WB, ELISA

Synonyms: MAPKAP 1, MAPKAP1, MEKK2 interacting protein 1, MGC2745, MIP 1, MIP1, Mitogen activated protein kinase associated protein 1, Mitogen-activated protein kinase 2-associated protein 1, mSIN1, OTTHUMP00000064207, Ras inhibitor MGC2745, SAPK interacting protein 1, SAPK-interacting protein 1, SIN 1, SIN1_HUMAN, SIN1b, SIN1g, Stress activated map kinase interacting protein 1, Stress activated protein kinase interacting 1, Stress-activated map kinase-interacting protein 1, Target of rapamycin complex 2 subunit MAPKAP1, TORC2 subunit MAPKAP1,

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.

Subcellular Location:
Cytosol, Golgi apparatus, Nucleus, Plasma Membrane,

Subunit Structure:
All isoforms except isoform 4 can be incorporated into the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts with ATF2, MAP3K2 and MAPK8. Interacts with GTP-bound HRAS and KRAS. Interacts with IFNAR2 and SGK1. Isoform 2 interacts with NBN. Isoform 1 interacts with CCDC28B.

Belongs to the SIN1 family.

Specificity: Sin1 Antibody detects endogenous levels of Sin1

A synthesized peptide derived from human Sin1

Purification: Immunogen affinity purified

Concentration: 1mg/ml

predicted Mw: 59.123

Uniprot ID: Q9BPZ7
Gene ID: 79109

Buffer & Storage: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?C.Stable for 12 months from date of receipt

For research use only, not for use in diagnostic procedure.