Sin1 polyclonal, anti-human, mouse

Sin1 polyclonal, anti-human, mouse

€0.00
In stock
SKU
AF7936
Catalog Number: AF7936

Isotype: Rabbit IgG

Applications: WB, ELISA

Synonyms: MAPKAP 1, MAPKAP1, MEKK2 interacting protein 1, MGC2745, MIP 1, MIP1, Mitogen activated protein kinase associated protein 1, Mitogen-activated protein kinase 2-associated protein 1, mSIN1, OTTHUMP00000064207, Ras inhibitor MGC2745, SAPK interacting protein 1, SAPK-interacting protein 1, SIN 1, SIN1_HUMAN, SIN1b, SIN1g, Stress activated map kinase interacting protein 1, Stress activated protein kinase interacting 1, Stress-activated map kinase-interacting protein 1, Target of rapamycin complex 2 subunit MAPKAP1, TORC2 subunit MAPKAP1,


Function:
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.

Subcellular Location:
Cytosol, Golgi apparatus, Nucleus, Plasma Membrane,

Subunit Structure:
All isoforms except isoform 4 can be incorporated into the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts with ATF2, MAP3K2 and MAPK8. Interacts with GTP-bound HRAS and KRAS. Interacts with IFNAR2 and SGK1. Isoform 2 interacts with NBN. Isoform 1 interacts with CCDC28B.

Similarity:
Belongs to the SIN1 family.

Specificity: Sin1 Antibody detects endogenous levels of Sin1

Immunogen:
A synthesized peptide derived from human Sin1

Purification: Immunogen affinity purified

Concentration: 1mg/ml

predicted Mw: 59.123

Gene: MAPKAP1
Uniprot ID: Q9BPZ7
Gene ID: 79109

Buffer & Storage: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?C.Stable for 12 months from date of receipt

For research use only, not for use in diagnostic procedure.

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