14-3-3 beta / alpha (clone N14), anti-human, mouse, rat

Background:
14-3-3 proteins are a family of conserved regulatory HYPERLINK "http://en.wikipedia.org/wiki/Molecule" \o "Molecule"molecules expressed in all HYPERLINK "http://en.wikipedia.org/wiki/Eukaryote" \o "Eukaryote"eukaryotic cells.They have the ability to bind a multitude of functionally diverse HYPERLINK "http://en.wikipedia.org/wiki/Signal_transduction" \o "Signal transduction"signaling proteins, including HYPERLINK "http://en.wikipedia.org/wiki/Kinase" \o "Kinase"kinases, HYPERLINK "http://en.wikipedia.org/wiki/Phosphatase" \o "Phosphatase" phosphatases, and HYPERLINK "http://en.wikipedia.org/wiki/Transmembrane_receptor" \o "Transmembrane receptor" transmembrane receptors. More than 100 signaling proteins have been reported as 14-3-3 ligands, 14-3-3 b/a is one of them. They play important roles in a wide range of vital regulatory processes, such as mitogenic signal transduction, apoptotic cell death, and cell cycle control. Elevated amounts of 14-3-3 proteins are found in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.[1]

Immunogen:
A synthetic peptide (conjugated with KLH)corresponding to the C-terminal of mouse14-3-3 beta / alpha.

Recommended Application:
Western Blot, WB(1:500-1000); Immunohistochemistry, IHC-P(1:100); Immunocytochemistry, ICC (1:50)

Product Form: Liquid

Purification: Protein A purified

Storage Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol and 0.05% Sodium Azide.

Storage Instruction:
Store at 4℃ after thawing (1 week). Aliquot and store at -20℃ for long term (at least one year). Avoid repeated freeze and thaw cycles.