14-3-3 (Ser58) polyclonal, anti-human, mouse, bovine, dog, chicken, sheep, Xenopus, zebrafish

Protein Family: Chaperones and Folding Catalysts

Pathway and Disease: Cell Growth and Death, Nervous and Sensory Systems

Description:
14-3-3 protein beta/alpha (14-3-3) is an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. p1433-58 binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. p1433-58 binding generally results in the modulation of the activity of the binding partner. p1433-58 is a negative regulator of osteogenesis. Recent work has demonstrated that the dimeric status of the 14-3-3 protein is regulated by site-specific serine phosphorylation.

Alternate Names: 14-3-3 protein beta/alpha, Prepronerve growth factor RNH-1, Protein kinase C inhibitor protein 1, KCIP-1, Ywhab

Application Notes: E: 1:1,000; E: 1:1,000; WB: 1:1,000; IHC: 1:500

Accession No.: P35213

Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser58 of rat 14-3-3.

Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.