14-3-3 sigma (Phospho Ser186) Rabbit polyclonal antibody, anti-human, mouse

Background:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners| usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17| regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.|p53-regulated inhibitor of G2/M progression.|Belongs to the 14-3-3 family.|subcellular location:May be secreted by a non-classical secretory pathway.|subunit:Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7| EIF4A1| ARHGAP1| VPS26A| VPS29| VPS35 and SFN.|tissue specificity:Present mainly in tissues enriched in stratified squamous keratinising epithelium.|

Research Area: Neuroscience, Signal transduction, Stem cells

Synonyms: Stratifin, 14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year