14-3-3 sigma Picoband polyclonal, anti-human, mouse, rat
€455.00
In stock
SKU
AC-ABO10154
Catalog Number: AC-ABO10154
Size: 100 µg
Isotype: Rabbit IgG
Applications: WB, E
Datasheet
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Size: 100 µg
Isotype: Rabbit IgG
Applications: WB, E
Datasheet
Request Information
Description: Rabbit IgG polyclonal antibody for 14-3-3 sigma detection. Tested with WB, Direct ELISA in Human;Mouse;Rat.
Protein Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
Other Names: 14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1
Subcellular Localization: Cytoplasm. Nucleus . Secreted. May be secreted by a non-classical secretory pathway.
Tissue Specificity: Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
Gene ID: 2810
Immunogen: E. coli-derived human 14-3-3 sigma recombinant protein (Position: M1-S248).
Calculated MW: 27774
Format: Lyophilized
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Storage: At -20˚C; for one year. After reconstitution, at 4˚C; for one month. It can also be aliquotted and stored frozen at -20˚C; for a longer time. Avoid repeated freezing and thawing.
Protein Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
Other Names: 14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1
Subcellular Localization: Cytoplasm. Nucleus . Secreted. May be secreted by a non-classical secretory pathway.
Tissue Specificity: Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
Gene ID: 2810
Immunogen: E. coli-derived human 14-3-3 sigma recombinant protein (Position: M1-S248).
Calculated MW: 27774
Format: Lyophilized
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Storage: At -20˚C; for one year. After reconstitution, at 4˚C; for one month. It can also be aliquotted and stored frozen at -20˚C; for a longer time. Avoid repeated freezing and thawing.
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