53BP1 Polyclonal Antibody

Background:
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
TP53BP1, 53BP1, TDRD30, TP53, p202, p53BP1

Immunogen: Recombinant fusion protein of human 53BP1 (NP_001135452.1).

Swissprot: Q12888
Gene ID: 7158

Calculated MW: 213 kDa/214 kDa
Observed MW: 255 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.