5HT1A Receptor polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
HTR1A(5-HYDROXYTRYPTAMINE RECEPTOR 1A), also called SEROTONIN 5-HT-1A RECEPTOR or BETA-2-ADRENERGIC RECEPTOR-LIKE PROTEIN G-21, is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor(GPCR) that is coupled to Gi/Go and mediates inhibitory neurotransmission. HTR1A denotes the human gene encoding for the receptor.The HTR1A gene is located at 5q12.3. The decreases in 5-HT-1A receptor densities correlated with decreased glucose utilization as measured by PET scan. Activation of 5-HT-1A receptors has been demonstrated to impair cognition, learning, and memory by inhibiting the release of glutamate and acetylcholine in various areas of the brain. 5-HT-1A receptors in the dorsal raphe nucleus are co-localized with neurokinin 1(NK1) receptors and have been shown to inhibit the release of substance P, their endogenous ligand.

Description:
Rabbit IgG polyclonal antibody for 5-hydroxytryptamine receptor 1A (HTR1A) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
5 HT 1A antibody, 5 HT receptor 1A antibody, 5 HT1A antibody, 5 HT1A receptor antibody, 5 hydroxytryptamine(serotonin) receptor 1A antibody, 5 hydroxytryptamine(serotonin) receptor 1A G protein coupled antibody, 5 hydroxytryptamine receptor 1A antibody, 5-HT-1A antibody, 5-HT1A antibody, 5-hydroxytryptamine receptor 1A antibody, 5HT 1A antibody, 5HT 1A receptor antibody, 5HT receptor 1A antibody, 5HT1a antibody, 5HT1A_HUMAN antibody, ADRB2RL1 antibody, ADRBRL1 antibody, G 21 antibody, G protein coupled receptor antibody, G-21 antibody, Gpcr 18 antibody, Gpcr18 antibody, Guanine nucleotide binding regulatory protein-coupled receptor antibody, HTR1A antibody, PFMCD antibody, Serotonin 1A receptor antibody, Serotonin 5HT1A receptor antibody, Serotonin receptor 1A antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human 5HT1A Receptor(404-422aa NKDFQNAFKKIIKCKFCRQ), different from the related rat and mouse sequences by one amino acid.A synthetic peptide corresponding to a sequence at the C-terminus of human 5HT1A Receptor(404-422aa NKDFQNAFKKIIKCKFCRQ), different from the related rat and mouse sequences by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.