5T4 polyclonal, anti-human, mouse, rat

Background:
TPBG (trophoblast glycoprotein), also known as 5T4, M6P1 or 5T4AG, is a 420 amino acid single-pass type I membrane protein expressed by all types of trophoblasts as early as 9 weeks of development. TPBG contains an N-terminal putative signal sequence, a 310-residue extracellular region, a membrane anchorage domain and a 44-amino acid cytoplasmic tail with a potential phosphorylation site. The extracellular region has seven potential N-glycosylation sites and seven leucine-rich repeats, which are located in two regions separated by a hydrophilic stretch. Suggested to be involved in cell adhesion, TPBG may also be associated with tumor growth and progression.

Alternative Name:
5T4 oncotrophoblast glycoprotein, WAIF1, TPBG, 5T4, 5T4 oncofetal antigen, 5T4 oncofetal trophoblast glycoprotein, 5T4 oncotrophoblast glycoprotein, 5T4AG, AW495680, M6P1, TPBG, TPBG, Trophoblast glycoprotein,

Application Dilution:
WB:1:1,000-1:5,000

Specificity: 5T4 polyclonal antibody detects endogenous levels of 5T4 protein.

Immunogen:
recombinant protein

MW: 72 kDa

Swiss-Prot: Q13641(Human) Q9Z0L0(Mouse) Q5PQV5(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.