a-actinin (4A12) Mouse mAb

Background:
α-Actinin belongs to the spectrin family of cytoskeletal proteins. α-Actinin is necessary for the attachment of actin filaments to the Z-lines in skeletal muscle cells, and to the dense bodies in smooth muscle cells. The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinated contractions between sarcomeres in the horizontal axis.

Cellular localization: Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Specificity: Human

Alternative Names:
actinin 1 smooth muscle antibody, actinin alpha 1 antibody, ACTN 1 antibody, FLJ40884 antibody

Immunogen: Recombinant Protein

Isotype: Mouse Monoclonal IgG1

Concentration: 1mg/ml

Recommended dilutions: IHC 1:100-200

Observed band: 103kDa

GeneID: 87

Swiss-Prot No.: P12814

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Store at -20°C. Avoid repeated freeze-thaw cycles.

NOTE: For Research Use Only