A Cyclase IV rabbit polyclonal, anti-human, mouse, rat

Backgroud: This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010],catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex.,function:This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,

Synonyms: ADCY4, Adenylate cyclase type 4, ATP pyrophosphate-lyase 4, Adenylate cyclase type IV, Adenylyl cyclase 4

Gene Name: ADCY4

Gene ID: 196883

SwissProt ID: Q8NFM4

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.