AANAT Polyclonal Antibody

Background:
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Metabolism, Neuroscience

Synonyms:
AA-NAT, Aanat, Aralkylamine N-acetyltransferase, Arylalkylamine N acetyltransferase, Serotonin acetylase, Serotonin N-acetyltransferase, SNAT, SNAT

Immunogen: Recombinant protein of human AANAT

Swissprot: Q16613
Gene Accession: BC069434

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.2 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-55612/sc-68346