AARS Polyclonal Antibody

Background:
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.

Research Area: Epigenetics and Nuclear Signaling

Synonyms:
AARS, AI316495, Alanine tRNA ligase 1, cytoplasmic, Alanine tRNA ligase, Alanine tRNA ligase cytoplasmic, Alanine--tRNA ligase, Alanyl tRNA synthetase, Alanyl tRNA synthetase cytoplasmic, Alanyl-tRNA synthetase, AlaRS, C76919, CMT2N, cytoplasmic, EC 6.1.1.7, MGC37368, Renal carcinoma antigen NY REN 42, Renal carcinoma antigen NY-REN-42, SYAC

Immunogen: Synthetic peptide of human AARS

Swissprot: P49588
Gene Accession: NP_001596

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-74698/sc-74699/sc-98547