ABCA4 polyclonal, anti-mouse, rat

Quantity: 100 µg

Background:
ABCA4(ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein which in humans is encoded by the ABCA4 gene. ABCA4 is a member of the ATP-binding cassette transporter gene sub-family A(ABC1) found exclusively in multicellular eukaryotes. Using a whole genome radiation hybrid panel, Allikmets et al.(1997) mapped the ABCR gene to 1p21-p13. Allikmets et al.(1997) localized ABCR transcripts exclusively within photoreceptor cells, indicating that ABCR mediates the transport of an essential molecule(or ion) either into or out of photoreceptor cells. Molday et al.(2000) showed by immunofluorescence microscopy and Western blot analysis that ABCR is present in foveal and peripheral cone, as well as rod, photoreceptors. The results suggested that the loss in central vision experienced by patients with Stargardt macular dystrophy arises directly from ABCR-mediated foveal cone degeneration.

Description:
Rabbit IgG polyclonal antibody for Retinal-specific ATP-binding cassette transporter (ABCA4) detection. Tested with WB in Mouse, Rat.

Synonyms:
ABC 10 antibody, ABC A4 antibody, ABC10 antibody, ABCA 4 antibody, abcA4 antibody, ABCA4_HUMAN antibody, ABCR antibody, ARMD 2 antibody, ARMD2 antibody, ATP binding cassette 10 antibody, ATP binding cassette sub family A member 4 antibody, ATP binding cassette sub family A member4 antibody, ATP binding cassette transporter antibody, ATP binding cassette transporter retinal specific antibody, ATP binding cassette, sub family A(ABC1), member 4 antibody, ATP binding cassette, sub family A(ABC1), member4 antibody, ATP binding cassette10 antibody, ATP binding transporter, retina specific antibody, ATP-binding cassette sub-family A member 4 antibody, CORD 3 antibody, CORD3 antibody, DKFZp781N1972 antibody, FFM antibody, FLJ17534 antibody, Photoreceptor rim protein antibody, Retina specific ABC transporter antibody, Retinal specific ATP binding cassette transporter antibody, Retinal-specific ATP-binding cassette transporter antibody, RIM ABC transporter antibody, RIM protein antibody, RmP antibody, RP 19 antibody, RP19 antibody, Stargardt disease protein antibody, STGD antibody, STGD1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of mouse ABCA4(1892-1903aa TLLIQHHFFLTR), identical to the related rat sequence.A synthetic peptide corresponding to a sequence at the C-terminus of mouse ABCA4(1892-1903aa TLLIQHHFFLTR), identical to the related rat sequence.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: mouse
Predicted to work with: rat

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.