ABCA6 rabbit polyclonal, anti-human, mouse, rat

Backgroud: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24 and may play a role in macrophage lipid homeostasis. [provided by RefSeq, Jul 2008],developmental stage:Expressed in fetal kidney, lung and liver.,function:Probable transporter which may play a role in macrophage lipid homeostasis.,induction:Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages.,similarity:Belongs to the ABC transporter family. ABCA subfamily.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Widely expressed with higher expression in liver.,

Synonyms: ABCA6, ATP-binding cassette sub-family A member 6

Gene Name: ABCA6

Gene ID: 23460

SwissProt ID: Q8N139

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.