ABCB11 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Bile Salt Export Pump (BSEP) is a protein which in humans is encoded by the ABCB 11 gene. It is a member of the superfamily of ATP-binding cassette (ABC) transporters, also known as ABCB11. It is mapped to chromosome 2q24. The BSEP protein is mainly expressed in the liver. ABCB11 is a gene associated with progressive familial intrahepatic cholestasis type 2 (PFIC2) which caused by mutations in the ABCB11 gene will increases the risk of hepatocellular carcinoma in early life.

Description:
Rabbit IgG polyclonal antibody for Bile salt export pump (ABCB11) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
ABC member 16, MDR/TAP subfamily antibody, ABCB1 antibody, Abcb11 antibody, ABCBB_HUMAN antibody, ATP binding cassette sub family B (MDR/TAP) member 11 antibody, ATP binding cassette sub family B member 11 antibody, ATP-binding cassette sub-family B member 11 antibody, Bile salt export pump antibody, BRIC2 antibody, Bsep antibody, PGY4 antibody, progressive familial intrahepatic cholestasis 2 antibody, Sister of P glycoprotein antibody, Spgp antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human ABCB11 (1175-1199aa KYGDNTKEIPMERVIAAAKQAQLHD), different from the related mouse and rat sequences by three amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.