ABCB4 Polyclonal Antibody

Background:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.

Research Area: Cancer, Metabolism, Signal transduction

Synonyms:
ABC 21, ABC B4, ABC21, ABCB 4, Abcb4, ABCB4 protein, ATP binding cassette sub family B MDR/TAP member 4, ATP binding cassette sub family B member 4, ATP-binding cassette sub-family B member 4, GBD1, ICP3, MDR 3, MDR2, MDR2/3, MDR3, MDR3 P glycoprotein, MDR3 P gp, MDR3, Multidrug resistance protein 3, Multiple drug resistance 3, P glycoprotein 3 , P-glycoprotein 3, PFIC 3, PFIC3, PGY 3, PGY3

Immunogen: Synthetic peptide of human ABCB4

Swissprot: P21439
Gene Accession: NP000434

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.2 mg/mL
Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.