ABCC2 Polyclonal Antibody

Background:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.

Research Area: Cancer, Metabolism, Signal transduction

Synonyms:
ABC30, abcC2, ATP binding cassette sub family C (CFTR/MRP) member 2, ATP binding cassette subfamily C member 2, ATP-binding cassette sub-family C member 2, Canalicular multidrug resistance protein, Canalicular multispecific organic anion transporter 1, CMOAT, CMOAT1, cMRP, DJS, KIAA1010, MRP 2, MRP2, Multidrug resistance associated protein 2, Multidrug resistance-associated protein 2

Immunogen: Synthetic peptide of human ABCC2

Swissprot: Q92887
Gene Accession: NP_000383

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: IHC 1:30-150, ELISA 1:2000-10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-5770/sc-28288/sc-28289/sc-20766