ABCC5 Polyclonal Antibody
€0.00
In stock
SKU
E-AB-12566
Catalog Number: E-AB-12566
Isotype: Rabbit IgG
Reactivity: human, mouse, rat
Applications: WB,IHC,ELISA
Datasheet, Questions? Contact us!
Isotype: Rabbit IgG
Reactivity: human, mouse, rat
Applications: WB,IHC,ELISA
Datasheet, Questions? Contact us!
Background:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.
Research Area: Cancer, Metabolism, Signal Transduction
Synonyms:
ABC 33, ABC33, ABCC 5, Abcc5, ATP binding cassette sub family C (CFTR/MRP) member 5, ATP binding cassette sub family C member 5, ATP-binding cassette sub-family C member 5, Canalicular multispecific organic anion transporter C, DKFZp686C1782, EST277145, MOAT C, MOAT-C, MOATC, MRP 5, MRP5, Multi specific organic anion tranporter C, Multi-specific organic anion transporter C, Multidrug resistance associated protein 5, Multidrug resistance-associated protein 5, pABC 11, pABC11, SMRP
Immunogen: Synthetic peptide of human ABCC5
Swissprot: O15440
Gene Accession: NP_005679
Calculated MW: 161 kDa
Purification Method: Affinity purification
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration: 0.5 mg/mL
Dilution: WB 1:1000-1:5000, IHC 1:50-1:200
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Alternative for product with catalog number:
sc-5780/sc-5778/sc-5781/sc-20769
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.
Research Area: Cancer, Metabolism, Signal Transduction
Synonyms:
ABC 33, ABC33, ABCC 5, Abcc5, ATP binding cassette sub family C (CFTR/MRP) member 5, ATP binding cassette sub family C member 5, ATP-binding cassette sub-family C member 5, Canalicular multispecific organic anion transporter C, DKFZp686C1782, EST277145, MOAT C, MOAT-C, MOATC, MRP 5, MRP5, Multi specific organic anion tranporter C, Multi-specific organic anion transporter C, Multidrug resistance associated protein 5, Multidrug resistance-associated protein 5, pABC 11, pABC11, SMRP
Immunogen: Synthetic peptide of human ABCC5
Swissprot: O15440
Gene Accession: NP_005679
Calculated MW: 161 kDa
Purification Method: Affinity purification
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration: 0.5 mg/mL
Dilution: WB 1:1000-1:5000, IHC 1:50-1:200
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Alternative for product with catalog number:
sc-5780/sc-5778/sc-5781/sc-20769
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