ABCG2/Bcrp monoclonal, anti-human

Description: Anti-ABCG2/Bcrp Rabbit Monoclonal Antibody . Tested in WB application. This antibody reacts with Human.

Protein Function:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin..

Other Names: Broad substrate specificity ATP-binding cassette transporter ABCG2, 7.6.2.2, ATP-binding cassette sub-family G member 2, Breast cancer resistance protein, CDw338, Mitoxantrone resistance-associated protein, Placenta-specific ATP-binding cassette transporter, Urate exporter, CD338, ABCG2, ABCP, BCRP, BCRP1, MXR

Clone Name(s):
Clone: AODG-1

Subcellular Localization: Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.

Tissue Specificity: Highly expressed in placenta. Low expression in small intestine, liver and colon..

Gene ID: 9429

Immunogen: A synthesized peptide derived from human ABCG2

Calculated MW: 72314

Purification: Affinity-chromatography

Format: Liquid

Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.