ABCG2 polyclonal, anti-human, mouse

Background:
ATP-binding cassette (ABC) transporters are an evolutionarily conserved family of proteins that catalyze the transport of molecules across extracellular and intracellular membranes through the energy of ATP hydrolysis. The ABC half-transporter, ABCG2, is also known as placenta-specific ABC transporter and breast cancer resistance protein (BCRP1). ABCG2 confers resistance for a variety of chemotherapeutic agents, including anthracyclines, mitoxantrone, bisantrene and topotecan. Under normal conditions, ABCG2 may serve a protective function by removing toxins from the cell, and plays an important role in regulating stem cell differentiation. ABCG2 is responsible for the side population (SP) phenotype and is widely expressed in a large variety of stem cells, making it an important stem cell marker. ABCG2 may have N-linked glycosylation and may dimerize in vivo. ABCG2 is abundantly expressed in placenta, liver, intestine and stem cells.

Alternative Name:
ABCG2, ABC transporter, ABC15, ABCG 2, ABCG2, ABCG2, ABCP, ATP binding cassette sub family G (WHITE) member 2, ATP binding cassette transporter G2, ATP-binding cassette sub-family G member 2, BCRP, BCRP1, BMDP, Breast cancer resistance protein, CD338, CDw338, CDw338 antigen, EST157481, GOUT1, MGC102821, Mitoxantrone resistance associated protein, Mitoxantrone resistance-associated protein, MRX, Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2, MXR, MXR1, Placenta specific ATP binding cassette transporter, Placenta specific MDR protein, Placenta-specific ATP-binding cassette transporter, UAQTL1,

Application Dilution:
WB:1:1,000-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: ABCG2 polyclonal antibody detects endogenous levels of ABCG2 protein.

Immunogen:
recombinant protein

MW: 72 kDa

Swiss-Prot: Q9UNQ0(Human) Q7TMS5(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.