ABI1 Polyclonal Antibody

Background:
This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14

Research Area: Cell Biology, Signal Transduction

Synonyms:
Abelson interactor 1, Abi-1, Abi1, ABI1, Abl binding protein 4, Abl interactor 1, Abl interactor protein 1, Abl-binding protein 4, AblBP4, e3B1, Eps8 binding protein, Eps8 SH3 domain binding protein, Eps8 SH3 domain-binding protein, Eps8-binding protein, Hssh3bp1, Interactor protein AblBP4, NAP1, Nap1 binding protein, Nap1-binding protein, Nap1BP, Spectrin SH3 domain binding protein 1, Spectrin SH3 domain-binding protein 1, SSH3BP

Immunogen: Synthetic peptide of human ABI1

Swissprot: Q8IZP0
Gene Accession: NP_005461

Calculated MW: 55 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-20323/sc-30038