Abin-2 rabbit polyclonal, anti-human, mouse, rat

Backgroud: This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014],function:Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation.,subunit:Interacts with STK11, TNFAIP3, IKBKG, NFKB1, MAP3K8 and RIPK1.,tissue specificity:Ubiquitously expressed in all tissues examined.,

Synonyms: TNFAIP3-interacting protein 2 (A20-binding inhibitor of NF-kappa-B activation 2, ABIN-2, Fetal liver LKB1-interacting protein)

Gene Name: TNIP2 ABIN2 FLIP1

Gene ID: 79155

SwissProt ID: Q8NFZ5

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.