ABL1 polyclonal, anti-human, mouse, rat

Background:
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

Synonyms: ABL, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl

Cellular Location: Cytoplasm Lipid-anchor Mitochondrion Nucleus Nucleus membrane cytoskeleton

Immunogen:
A synthetic peptide of human ABL1

Gene Symbol: ABL1

Gene ID: 25

Swiss prot: P00519

Calculated MW: 123kDa

Recommended dilution:
WB 1:500-2000, IHC 1:100-200, IF 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.