ABL1 Polyclonal Antibody

Background:
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.

Research Area: Signal Transduction, Epigenetics and Nuclear Signaling, Cancer

Synonyms:
Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine protein kinase 1, Abl 1, ABL, bcr/abl, c ABL, c abl oncogene 1 receptor tyrosine kinase, JTK7, p150, Proto-oncogene c-Abl, Tyrosine-protein kinase ABL1, v abl

Immunogen: Recombinant Human Tyrosine-protein kinase ABL1 protein

Swissprot: P00519
Gene ID: 25

Purification Method: Antigen Affinity Purification

Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3

Concentration: 0.24 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.