ABL2 polyclonal, anti-human, mouse, rat

Background:
The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including chronic myelocytic leukemia (CML), in which it undergoes a (9,22) chromosomal translocation and produces the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein tyrosine kinase. The related protein tyrosine kinase Arg, also designated Abl2, contains an SH2 and an SH3 domain. Arg has been shown to interact with and to phosphorylate c-Crk.

Alternative Name:
ABL2, Abelson murine leukemia viral oncogene homolog 2, Abelson related gene protein, Abelson tyrosine-protein kinase 2, Abelson-related gene protein, ABL2, ABL2, ABLL, ARG, Tyrosine kinase ARG, Tyrosine protein kinase ABL2, Tyrosine-protein kinase ARG, v abl Abelson murine leukemia viral oncogene homolog 2,

Application Dilution:
WB:1:1,000-1:2,000
FC:1:50-1:100

Specificity: ABL2 polyclonal antibody detects endogenous levels of ABL2 protein.

Immunogen:
recombinant protein

MW: 128 kDa

Swiss-Prot: P42684(Human) Q4JIM5(Mouse) Unigene:69847(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.