ACCN2 polyclonal, anti-human, mouse, rat

Background:
Isoform 2 and isoform 3 function as proton-gated sodium channels, they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.Isoform 1 does not display proton-gated cation channel activity.

Alternative Name:
ASIC1, BNaC2, ASIC1, ACCN2, BNAC2, ACCN2, ACCN2, Acid sensing ion channel 1, Acid sensing ion channel 1a protein, Acid sensing ion channel, Acid-sensing ion channel 1, AI843610, Amiloride sensitive cation channel 2 neuronal, Amiloride-sensitive cation channel 2, ASIC, ASIC1, ASIC1A, B530003N02Rik, BNaC2, Brain sodium channel 2, Cation channel amiloride sensitive neuronal 2, hBNaC2, neuronal,

Application Dilution:
WB:1:500-1:2,000
IHC:1:50-1:200
FC:1:50-1:100

Specificity: ACCN2 polyclonal antibody detects endogenous levels of ACCN2 protein.

Immunogen:
Synthetic peptide within human ACCN2 aa 460-500.

MW: 60 kDa

Swiss-Prot: P78348(Human) Q6NXK8(Mouse) P55926(Rat)

Purification & Purity:
Peptide affinity purified.

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.