ACE monoclonal (Ascites), anti-mouse

Background:
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active.

Other Names:
Angiotensin-converting enzyme, ACE, 321-, Dipeptidyl carboxypeptidase I, Kininase II, CD143, Angiotensin-converting enzyme, soluble form, ACE, DCP, DCP1

Target/Specificity:
This ACE antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 1274-1306 amino acids from human ACE.

Antigen Region:
1274-1306

Antigen Type: Synthetic Peptide

Gene Name: ACE {ECO:0000303|PubMed:2849100, ECO:0000312|HGNC:HGNC:2707}
Gene ID: 1636
Primary Accession: P12821
NCBI Accession: NP_000780.1;NP_001171528.1;NP_690043.1
Other Accession: NP_000780
Format: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.