ACE polyclonal, anti-human, mouse

Background:
Angiotensin-converting enzyme (ACE) is a carboxy-terminal dipeptidyl exo-peptidase that converts Angiotensin I to the potent vasopressive hormone, Angiotensin II. There are two isoforms of ACE, the pulmonary ACEP and the testicular ACET. ACEP is a glycoprotein expressed in vascular endothelial cells of the lung, liver, adrenal cortex, pancreas, kidney and spleen. The ACET isoform is expressed exclusively in adult testis by developing sperm cells, specifically, late pachytene spermatocytes. Additionally, ACE inactivates bradykinin, a vasodepressor peptide, and is involved in fluid/electrolyte homeostasis. Although it bears significant sequence homology to ACE, ACE2 shows a more restricted pattern of expression. ACE is expressed ubiquitously throughout the vasculature while ACE2 is expressed only in cardiac, renal and testicular cells.

Alternative Name:
ACE, DCP, DCP1, ACE 1, ACE, ACE T, ACE, ACE1, Angiotensin converting enzyme somatic isoform, Angiotensin converting enzyme testis specific isoform, Angiotensin I converting enzyme 1, Angiotensin I converting enzyme, Angiotensin I converting enzyme peptidyl dipeptidase A 1, angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript, Angiotensin-converting enzyme, Carboxycathepsin, CD 143, CD143, CD143 antigen, DCP 1, DCP, DCP1, Dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, Kininase II, MGC26566, MVCD3, Peptidase P, Peptidyl dipeptidase A, soluble form, Testicular ECA,

Application Dilution:
WB:1:500-1:2,000
IHC:1:100-1:500
FC:1:50-1:100

Specificity: ACE polyclonal antibody detects endogenous levels of ACE protein.

Immunogen:
recombinant protein

MW: 160 kDa

Swiss-Prot: P12821(Human) P09470(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.