ACE1 Polyclonal Antibody

Background:
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active.

Research Area: Cancer, Cell Biology, Cardiovascular, Metabolism, Signal Transduction, Stem Cells

Synonyms:
ACE 1, ACE, ACE T, ACE, ACE1, Angiotensin converting enzyme somatic isoform, Angiotensin converting enzyme testis specific isoform, Angiotensin I converting enzyme 1, Angiotensin I converting enzyme, Angiotensin I converting enzyme peptidyl dipeptidase A 1, angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript, Angiotensin-converting enzyme, Carboxycathepsin, CD 143, CD143, CD143 antigen, DCP 1, DCP, DCP1, Dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, Kininase II, MGC26566, MVCD3, Peptidase P, Peptidyl dipeptidase A, soluble form, Testicular ECA

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse ACE

Swissprot: P09470,P47820

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 200 μg/mL
Dilution: IHC 1:300-1:1000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Citation(s):
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190919/