ACER1 Polyclonal Antibody

Background:
ACER1 (Alkaline Ceramidase 1) is a Protein Coding gene. Diseases associated with ACER1 include Corneal Dystrophy, Posterior Amorphous. Among its related pathways are Sphingolipid metabolism and Sphingolipid signaling pathway. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides and dihydroceramidase activity. An important paralog of this gene is ACER2.Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine.

Research Area: Cancer, Metabolism, Signal Transduction

Synonyms:
Acer1, ACER1, Acylsphingosine deacylase 3, Alkaline CDase 1, Alkaline ceramidase 1, Alkaline ceramidase, AlkCDase 1, ALKCDase1, ASAH 3, MGC138327, MGC138329, N acylsphingosine amidohydrolase (alkaline ceramidase) 3, N acylsphingosine amidohydrolase 3 alkaline ceramidase, N acylsphingosine amidohydrolase 3, N-acylsphingosine amidohydrolase 3

Immunogen: Synthetic peptide of human ACER1

Swissprot: Q8TDN7
Gene Accession: NP597999

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.2 mg/mL
Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.