Acetyl-Histone H4-K8 polyclonal, anti-human, mouse, rat

Background:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.

Synonyms: FO108, H4, H4/n, H4F2, H4FN, HIST2H4

Cellular Location: Chromosome Nucleus

Immunogen:
A synthetic peptide of human Acetyl-Histone H4-K8

Gene Symbol: Acetyl-Histone H4-K8

Gene ID: 8370

Swiss prot: P62805

Calculated MW: 11kDa

Recommended dilution:
WB 1:1000-3000, IHC 1:200-500, IF 1:500-1000, IP 1:200-500, ChIP 1:20-50, ChIPseq 1:20-50,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.