Acidic Hair Keratin K37 (hHa7) polyclonal, anti-human, chimpanzee

Quantity: 25 µl

Background:
The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription.

Synonyms:
KRT37, HA7, HKA7, hHa7, KRTHA7

Isotype: Guinea pig Polyclonal (GP-hHa7)

Immunogen:
Synthetic peptide of human acidic hair (trichocytic) keratin K37 (formerly also designated keratin hHa7; CGP VTG GSP SGH GAS MGR), coupled to KLH

Form: Stabilized Serum

Specificity:
The antiserum stains specifically human hair keratin K37 expressed starting from the middle cortex of vellous hairs. It is negative in the anagen hair follicle.

Reactivity: human, Chimpanzee

Applications: Immunohistochemistry on frozen sections, Immunoblotting

Working DIlution: 1:200 for immunohistochemistry; 1:2,000 for immunoblotting (ECL method)

Storage: 2-8C

References:
- Langbein, L. et al. (1999) J. Biol. Chem. 274: 19874-19893
- Jave-Suarez LF et al. (2004) J Invest Dermatol 122: 555-564
- Langbein L et al. (2004) Methods in Cell V Biology 78: 413-456