ACIN1 Polyclonal Antibody

Background:
Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism

Synonyms:
ACIN 1, ACIN1, ACINU, Acinus, ACN, Apoptotic chromatin condensation inducer 1, Apoptotic chromatin condensation inducer in the nucleus, DKFZp667N107, fSAP152, functional spliceosome-associated protein 152, KIAA0670

Immunogen: Synthetic peptide of human ACIN1

Swissprot: Q9UKV3
Gene Accession: NP_001158286

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-5433/sc-5435/sc-5434/sc-5432/sc-5430