ACK1 polyclonal (N-term), anti-human
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In stock
SKU
AC-AP7696a
Catalog Number: AC-AP7696a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB15601
Applications: FC, IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB15601
Applications: FC, IHC-P, WB
Datasheet
Request Information
Background:
ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.
Other Names:
Activated CDC42 kinase 1, ACK-1, Tyrosine kinase non-receptor protein 2, TNK2, ACK1
Target/Specificity:
This ACK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-39 amino acids from the N-terminal region of human ACK1.
Antigen Region:
10-39
Antigen Type: Synthetic Peptide
Gene Name: TNK2
Gene ID: 10188
Primary Accession: Q07912
NCBI Accession: NP_001010938.1;NP_005772.3
Other Accession: Q17R13
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.
Other Names:
Activated CDC42 kinase 1, ACK-1, Tyrosine kinase non-receptor protein 2, TNK2, ACK1
Target/Specificity:
This ACK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-39 amino acids from the N-terminal region of human ACK1.
Antigen Region:
10-39
Antigen Type: Synthetic Peptide
Gene Name: TNK2
Gene ID: 10188
Primary Accession: Q07912
NCBI Accession: NP_001010938.1;NP_005772.3
Other Accession: Q17R13
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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