ACO1 antibody (clone 2C1), anti-human
€435.00
In stock
SKU
AC-AT1026a
Catalog Number: AC-AT1026a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IP, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IP, E
Request Information AC-AT1026a">Request Information
Background:
Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
Other Names:
Cytoplasmic aconitate hydratase, Aconitase, Citrate hydro-lyase, Ferritin repressor protein, Iron regulatory protein 1, IRP1, Iron-responsive element-binding protein 1, IRE-BP 1, ACO1, IREB1
Antigen Type:
Recombinant Protein
Gene Name: ACO1
Gene ID: 48
NCBI Accession: NP_001265281.1;NP_002188.1
Primary Accession: P21399
Other Accession: BC018103
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
Other Names:
Cytoplasmic aconitate hydratase, Aconitase, Citrate hydro-lyase, Ferritin repressor protein, Iron regulatory protein 1, IRP1, Iron-responsive element-binding protein 1, IRE-BP 1, ACO1, IREB1
Antigen Type:
Recombinant Protein
Gene Name: ACO1
Gene ID: 48
NCBI Accession: NP_001265281.1;NP_002188.1
Primary Accession: P21399
Other Accession: BC018103
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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