ACO1 polyclonal, anti-human, mouse, rat

Background:
Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

Synonyms: IRP1, ACONS, IREB1, IREBP, IREBP1

Cellular Location: Cytoplasm

Immunogen:
A synthetic peptide of human ACO1

Gene Symbol: ACO1

Gene ID: 48

Swiss prot: P21399

Calculated MW: 98 kDa

Recommended dilution:
WB 1:1000-5000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.