ACO2 rabbit polyclonal, anti-human, mouse, rat, canine

Backgroud: The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008],catalytic activity:Citrate = isocitrate.,cofactor:Binds 1 4Fe-4S cluster per subunit. Binding of a 3Fe-4S cluster leads to an inactive enzyme.,online information:Aconitase entry,pathway:Carbohydrate metabolism; tricarboxylic acid cycle.,similarity:Belongs to the aconitase/IPM isomerase family.,subunit:Monomer.,

Synonyms: Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)

Gene Name: ACO2

Gene ID: 50

SwissProt ID: Q99798

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.