ACOD1 Polyclonal Antibody

Background:
Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.

Research Area: Metabolism, Immunology, Signal transduction

Synonyms:
ACOD1, Aconitate decarboxylase 1, Aconitate decarboxylase, CAD, Cis aconitate decarboxylase, Immune responsive gene 1 protein homolog, Immune-responsive gene 1 protein homolog, Immunoresponsive 1 homolog (mouse), Irg1, IRG1, OC116, OPTB1, TCTIRC7

Immunogen: Synthetic peptide of human ACOD1

Swissprot: A6NK06
Gene Accession: NP001245335

Calculated MW: 53 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.32 mg/mL
Dilution: WB 1:500-1:2000, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.