Actinin α polyclonal, anti-human, mouse, rat

Background:
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

Alternative Name:
ACTN1, actinin 1 smooth muscle, Actinin alpha 1, actinin, alpha 1, ACTN 1, Actn1, ACTN1, Alpha Actinin 1, Alpha actinin cytoskeletal isoform, Alpha-actinin cytoskeletal isoform, Alpha-actinin-1, BDPLT15, F actin cross linking protein, F-actin cross-linking protein, FLJ40884, FLJ54432, Non muscle alpha actinin 1, Non-muscle alpha-actinin-1,

Application Dilution:
WB:1:500-1:1,000
ICC:1:50-1:100
IHC:1:50-1:200
FC:1:50-1:100

Specificity: Actinin α polyclonal antibody detects endogenous levels of Actinin α protein.

Immunogen:
Recombinant protein within human alpha Actinin aa 350-650.

MW: 103 kDa

Swiss-Prot: P12814(Human) Q7TPR4(Mouse) Q9Z1P2(Rat)

Purification & Purity:
Protein affinity purified.

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.