Activin Receptor Type IIB (ACVR2A/B) Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP7104a
Background:
ACVR2A/B are activin A type II receptors. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
Other Names:
Activin receptor type-2A, Activin receptor type IIA, ACTR-IIA, ACTRIIA, ACVR2A, ACVR2
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7104a was selected from the Center region of human ACVR2A/B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ACVR2A (HGNC:173)
Gene ID: 92
Primary Accession: P27037
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
ACVR2A/B are activin A type II receptors. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
Other Names:
Activin receptor type-2A, Activin receptor type IIA, ACTR-IIA, ACTRIIA, ACVR2A, ACVR2
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7104a was selected from the Center region of human ACVR2A/B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ACVR2A (HGNC:173)
Gene ID: 92
Primary Accession: P27037
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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